New insights into the molecular control of the lymphatic vascular system and its role in disease.
Identifieur interne : 007901 ( Main/Exploration ); précédent : 007900; suivant : 007902New insights into the molecular control of the lymphatic vascular system and its role in disease.
Auteurs : Leah N. Cueni [Suisse] ; Michael DetmarSource :
- The Journal of investigative dermatology [ 0022-202X ] ; 2006.
Descripteurs français
- KwdFr :
- Animaux, Chimiokine CCL21, Chimiokines CC (physiologie), Endothélium lymphatique (physiologie), Facteur de croissance endothéliale vasculaire de type C (physiologie), Facteur de croissance endothéliale vasculaire de type D (physiologie), Glycoprotéines (physiologie), Humains, Lymphangiogenèse, Lymphoedème (), Lymphoedème (génétique), Métastase lymphatique, Protéines du transport vésiculaire, Récepteur-3 au facteur croissance endothéliale vasculaire (physiologie), Sarcome de Kaposi (étiologie), Vaisseaux lymphatiques (anatomie et histologie), Vaisseaux lymphatiques (embryologie), Vaisseaux lymphatiques (physiologie).
- MESH :
- anatomie et histologie : Vaisseaux lymphatiques.
- embryologie : Vaisseaux lymphatiques.
- génétique : Lymphoedème.
- physiologie : Chimiokines CC, Endothélium lymphatique, Facteur de croissance endothéliale vasculaire de type C, Facteur de croissance endothéliale vasculaire de type D, Glycoprotéines, Récepteur-3 au facteur croissance endothéliale vasculaire, Vaisseaux lymphatiques.
- étiologie : Sarcome de Kaposi.
- Animaux, Chimiokine CCL21, Humains, Lymphangiogenèse, Lymphoedème, Métastase lymphatique, Protéines du transport vésiculaire.
English descriptors
- KwdEn :
- Animals, Chemokine CCL21, Chemokines, CC (physiology), Endothelium, Lymphatic (physiology), Glycoproteins (physiology), Humans, Lymphangiogenesis, Lymphatic Metastasis, Lymphatic Vessels (anatomy & histology), Lymphatic Vessels (embryology), Lymphatic Vessels (physiology), Lymphedema (genetics), Lymphedema (therapy), Sarcoma, Kaposi (etiology), Vascular Endothelial Growth Factor C (physiology), Vascular Endothelial Growth Factor D (physiology), Vascular Endothelial Growth Factor Receptor-3 (physiology), Vesicular Transport Proteins.
- MESH :
- chemical , physiology : Chemokines, CC, Glycoproteins, Vascular Endothelial Growth Factor C, Vascular Endothelial Growth Factor D, Vascular Endothelial Growth Factor Receptor-3.
- chemical : Chemokine CCL21, Vesicular Transport Proteins.
- anatomy & histology : Lymphatic Vessels.
- embryology : Lymphatic Vessels.
- etiology : Sarcoma, Kaposi.
- genetics : Lymphedema.
- physiology : Endothelium, Lymphatic, Lymphatic Vessels.
- therapy : Lymphedema.
- Animals, Humans, Lymphangiogenesis, Lymphatic Metastasis.
Abstract
The cutaneous lymphatic system plays an important role in the maintenance of tissue fluid homeostasis, in the afferent phase of the immune response, and in the metastatic spread of skin cancers. However, the lymphatic system has not received as much scientific attention as the blood vascular system, largely due to a lack of lymphatic-specific markers and to the dearth of knowledge about the molecular regulation of its development and function. The recent identification of genes that specifically control lymphatic development and the growth of lymphatic vessels (lymphangiogenesis), together with the discovery of new lymphatic endothelium-specific markers, have now provided new insights into the molecular mechanisms that control lymphatic growth and function. Moreover, studies of several genetic mouse models have set the framework for a new molecular model for embryonic lymphatic vascular development, and have identified molecular pathways whose mutational inactivation leads to human diseases associated with lymphedema. These scientific advances have also provided surprising evidence that malignant tumors can directly promote lymphangiogenesis and lymphatic metastasis, and that lymphatic vessels play a major role in cutaneous inflammation and in the cutaneous response to UVB irradiation.
DOI: 10.1038/sj.jid.5700464
PubMed: 16983326
Affiliations:
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Cueni</name><affiliation wicri:level="1"><nlm:affiliation>Institute of Pharmaceutical Sciences, Swiss Federal Institute of Technology, ETH Zurich, Zurich, Switzerland.</nlm:affiliation><country xml:lang="fr">Suisse</country><wicri:regionArea>Institute of Pharmaceutical Sciences, Swiss Federal Institute of Technology, ETH Zurich, Zurich</wicri:regionArea><wicri:noRegion>Zurich</wicri:noRegion></affiliation></author><author><name sortKey="Detmar, Michael" sort="Detmar, Michael" uniqKey="Detmar M" first="Michael" last="Detmar">Michael Detmar</name></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2006">2006</date><idno type="RBID">pubmed:16983326</idno><idno type="pmid">16983326</idno><idno type="doi">10.1038/sj.jid.5700464</idno><idno type="wicri:Area/PubMed/Corpus">003881</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Corpus" wicri:corpus="PubMed">003881</idno><idno type="wicri:Area/PubMed/Curation">003881</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Curation">003881</idno><idno type="wicri:Area/PubMed/Checkpoint">003881</idno><idno type="wicri:explorRef" wicri:stream="Checkpoint" wicri:step="PubMed">003881</idno><idno type="wicri:Area/Ncbi/Merge">002404</idno><idno type="wicri:Area/Ncbi/Curation">002404</idno><idno type="wicri:Area/Ncbi/Checkpoint">002404</idno><idno type="wicri:doubleKey">0022-202X:2006:Cueni L:new:insights:into</idno><idno type="wicri:Area/Main/Merge">007A78</idno><idno type="wicri:Area/Main/Curation">007901</idno><idno type="wicri:Area/Main/Exploration">007901</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">New insights into the molecular control of the lymphatic vascular system and its role in disease.</title><author><name sortKey="Cueni, Leah N" sort="Cueni, Leah N" uniqKey="Cueni L" first="Leah N" last="Cueni">Leah N. Cueni</name><affiliation wicri:level="1"><nlm:affiliation>Institute of Pharmaceutical Sciences, Swiss Federal Institute of Technology, ETH Zurich, Zurich, Switzerland.</nlm:affiliation><country xml:lang="fr">Suisse</country><wicri:regionArea>Institute of Pharmaceutical Sciences, Swiss Federal Institute of Technology, ETH Zurich, Zurich</wicri:regionArea><wicri:noRegion>Zurich</wicri:noRegion></affiliation></author><author><name sortKey="Detmar, Michael" sort="Detmar, Michael" uniqKey="Detmar M" first="Michael" last="Detmar">Michael Detmar</name></author></analytic><series><title level="j">The Journal of investigative dermatology</title><idno type="ISSN">0022-202X</idno><imprint><date when="2006" type="published">2006</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Animals</term><term>Chemokine CCL21</term><term>Chemokines, CC (physiology)</term><term>Endothelium, Lymphatic (physiology)</term><term>Glycoproteins (physiology)</term><term>Humans</term><term>Lymphangiogenesis</term><term>Lymphatic Metastasis</term><term>Lymphatic Vessels (anatomy & histology)</term><term>Lymphatic Vessels (embryology)</term><term>Lymphatic Vessels (physiology)</term><term>Lymphedema (genetics)</term><term>Lymphedema (therapy)</term><term>Sarcoma, Kaposi (etiology)</term><term>Vascular Endothelial Growth Factor C (physiology)</term><term>Vascular Endothelial Growth Factor D (physiology)</term><term>Vascular Endothelial Growth Factor Receptor-3 (physiology)</term><term>Vesicular Transport Proteins</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>Animaux</term><term>Chimiokine CCL21</term><term>Chimiokines CC (physiologie)</term><term>Endothélium lymphatique (physiologie)</term><term>Facteur de croissance endothéliale vasculaire de type C (physiologie)</term><term>Facteur de croissance endothéliale vasculaire de type D (physiologie)</term><term>Glycoprotéines (physiologie)</term><term>Humains</term><term>Lymphangiogenèse</term><term>Lymphoedème ()</term><term>Lymphoedème (génétique)</term><term>Métastase lymphatique</term><term>Protéines du transport vésiculaire</term><term>Récepteur-3 au facteur croissance endothéliale vasculaire (physiologie)</term><term>Sarcome de Kaposi (étiologie)</term><term>Vaisseaux lymphatiques (anatomie et histologie)</term><term>Vaisseaux lymphatiques (embryologie)</term><term>Vaisseaux lymphatiques (physiologie)</term></keywords><keywords scheme="MESH" type="chemical" qualifier="physiology" xml:lang="en"><term>Chemokines, CC</term><term>Glycoproteins</term><term>Vascular Endothelial Growth Factor C</term><term>Vascular Endothelial Growth Factor D</term><term>Vascular Endothelial Growth Factor Receptor-3</term></keywords><keywords scheme="MESH" type="chemical" xml:lang="en"><term>Chemokine CCL21</term><term>Vesicular Transport Proteins</term></keywords><keywords scheme="MESH" qualifier="anatomie et histologie" xml:lang="fr"><term>Vaisseaux lymphatiques</term></keywords><keywords scheme="MESH" qualifier="anatomy & histology" xml:lang="en"><term>Lymphatic Vessels</term></keywords><keywords scheme="MESH" qualifier="embryologie" xml:lang="fr"><term>Vaisseaux lymphatiques</term></keywords><keywords scheme="MESH" qualifier="embryology" xml:lang="en"><term>Lymphatic Vessels</term></keywords><keywords scheme="MESH" qualifier="etiology" xml:lang="en"><term>Sarcoma, Kaposi</term></keywords><keywords scheme="MESH" qualifier="genetics" xml:lang="en"><term>Lymphedema</term></keywords><keywords scheme="MESH" qualifier="génétique" xml:lang="fr"><term>Lymphoedème</term></keywords><keywords scheme="MESH" qualifier="physiologie" xml:lang="fr"><term>Chimiokines CC</term><term>Endothélium lymphatique</term><term>Facteur de croissance endothéliale vasculaire de type C</term><term>Facteur de croissance endothéliale vasculaire de type D</term><term>Glycoprotéines</term><term>Récepteur-3 au facteur croissance endothéliale vasculaire</term><term>Vaisseaux lymphatiques</term></keywords><keywords scheme="MESH" qualifier="physiology" xml:lang="en"><term>Endothelium, Lymphatic</term><term>Lymphatic Vessels</term></keywords><keywords scheme="MESH" qualifier="therapy" xml:lang="en"><term>Lymphedema</term></keywords><keywords scheme="MESH" qualifier="étiologie" xml:lang="fr"><term>Sarcome de Kaposi</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Animals</term><term>Humans</term><term>Lymphangiogenesis</term><term>Lymphatic Metastasis</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>Animaux</term><term>Chimiokine CCL21</term><term>Humains</term><term>Lymphangiogenèse</term><term>Lymphoedème</term><term>Métastase lymphatique</term><term>Protéines du transport vésiculaire</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">The cutaneous lymphatic system plays an important role in the maintenance of tissue fluid homeostasis, in the afferent phase of the immune response, and in the metastatic spread of skin cancers. However, the lymphatic system has not received as much scientific attention as the blood vascular system, largely due to a lack of lymphatic-specific markers and to the dearth of knowledge about the molecular regulation of its development and function. The recent identification of genes that specifically control lymphatic development and the growth of lymphatic vessels (lymphangiogenesis), together with the discovery of new lymphatic endothelium-specific markers, have now provided new insights into the molecular mechanisms that control lymphatic growth and function. Moreover, studies of several genetic mouse models have set the framework for a new molecular model for embryonic lymphatic vascular development, and have identified molecular pathways whose mutational inactivation leads to human diseases associated with lymphedema. These scientific advances have also provided surprising evidence that malignant tumors can directly promote lymphangiogenesis and lymphatic metastasis, and that lymphatic vessels play a major role in cutaneous inflammation and in the cutaneous response to UVB irradiation.</div></front></TEI><affiliations><list><country><li>Suisse</li></country></list><tree><noCountry><name sortKey="Detmar, Michael" sort="Detmar, Michael" uniqKey="Detmar M" first="Michael" last="Detmar">Michael Detmar</name></noCountry><country name="Suisse"><noRegion><name sortKey="Cueni, Leah N" sort="Cueni, Leah N" uniqKey="Cueni L" first="Leah N" last="Cueni">Leah N. Cueni</name></noRegion></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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